Synthesis of 5-(ethylsulfonyl)-2-methoxyaniline: An important pharmacological fragment of VEGFR2 and other inhibitors

M Murár, G Addová, A Boháč

文献索引：Murar, Miroslav; Addova, Gabriela; Bohac, Andrej Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 173 - 179

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被引用次数: 9

摘要

Background: 5-(Ethylsulfonyl)-2-methoxyaniline (5) is part of the structure in 131 compounds possessing different biological activities. In most cases, they have antitumor properties (112 compounds). Other compounds are described as cardiovascular agents, ion-channel blockers, nervous-system blockers, anti-inflammatory agents, or antidiabetic, antiosteoporotic and hypolipemic species. Compound 5 is a precursor of different protein- ...