Preparation of chiral cyanohydrins by an oxynitrilase-mediated transcyanation

VI Ognyanov, VK Datcheva…

文献索引：Ognyanov, Vassil I.; Datcheva, Violeta K.; Kyler, Keith S. Journal of the American Chemical Society, 1991 , vol. 113, # 18 p. 6992 - 6996

全文：HTML全文

被引用次数: 132

摘要

Abstract: The transcyanation of aromatic and aliphatic aldehydes 1 (RCHO) with acetone cyanohydrin is catalyzed by the enzyme D-oxynitrilase to afford (R)-cyanohydrins 2 (RCH (0H) CN). The biocatalytic method using acetone cyanohydrin gives products of high enantiomeric purity with better consistency than similar conditions using hydrogen cyanide as the cyanide source. The use of an ether-buffer biphasic solvent system is essential for ...