Preparation of chiral cyanohydrins by an oxynitrilase-mediated transcyanation

VI Ognyanov, VK Datcheva…

Index: Ognyanov, Vassil I.; Datcheva, Violeta K.; Kyler, Keith S. Journal of the American Chemical Society, 1991 , vol. 113, # 18 p. 6992 - 6996

Full Text: HTML

Citation Number: 132

Abstract

Abstract: The transcyanation of aromatic and aliphatic aldehydes 1 (RCHO) with acetone cyanohydrin is catalyzed by the enzyme D-oxynitrilase to afford (R)-cyanohydrins 2 (RCH (0H) CN). The biocatalytic method using acetone cyanohydrin gives products of high enantiomeric purity with better consistency than similar conditions using hydrogen cyanide as the cyanide source. The use of an ether-buffer biphasic solvent system is essential for ...

First general methods toward aldehyde enolphosphates

[Barthes, Nicolas; Grison, Claude Bioorganic Chemistry, 2012 , vol. 40, # 1 p. 48 - 56]

Concise total synthesis of (+)-carpamic acid

[Randl, Stefan; Blechert, Siegfried Tetrahedron Letters, 2004 , vol. 45, # 6 p. 1167 - 1169]

A detailed identification study on high-temperature degradat...

[Berdeaux, Olivier; Fontagne, Stephanie; Semon, Etienne; Velasco, Joaquin; Sebedio, Jean Louis; Dobarganes, Carmen Chemistry and Physics of Lipids, 2012 , vol. 165, # 3 p. 338 - 347]

Studies related to fatty acid desaturation. I, Preparation o...

[Genard, S.; Patin, H. Bulletin de la Societe Chimique de France, 1991 , # 3 p. 397 - 406]