Tetrahedron: Asymmetry

An optimised synthetic approach to a chiral derivatising agent and the utilisation of a dimerisation reaction in the synthesis of a novel C2-symmetric diphosphine …

GD Williams, CE Wade, GJ Clarkson, M Wills

文献索引：Williams, Glynn D.; Wade, Charles E.; Clarkson, Guy J.; Wills, Martin Tetrahedron Asymmetry, 2007 , vol. 18, # 5 p. 664 - 670

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被引用次数: 12

摘要

We report an optimised synthetic approach to the chiral derivatising agent (5R)-methyl-1- (chloromethyl)-2-pyrrolidinone. In addition, the observation of an unwanted dimerisation product is turned to our advantage by providing a method for the synthesis of a new class of C2-symmetric chiral diphosphine.