Synthesis and biological properties of new 1β-methylcarbapenems having tetrazolothioether moiety
KJ Shin, KD Koo, KH Yoo, DC Kim, DJ Kim…
文献索引：Shin, Kye Jung; Koo, Ki Dong; Yoo, Kyung Ho; Kim, Dong Chan; Kim, Dong Jin; Park, Sang Woo Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 13 p. 1421 - 1425
The synthesis and biological activities of a series of new 1β-methylcarbapenems 1a–l having tetrazolothioether moiety at C-5 position of pyrrolidine were described. Among these compounds, 1c showed the most potent antibacterial activity and advanced pharmacokinetics compared with imipenem and meropenem.
