Synthesis and biological properties of new 1β-methylcarbapenems having tetrazolothioether moiety

KJ Shin, KD Koo, KH Yoo, DC Kim, DJ Kim…

Index: Shin, Kye Jung; Koo, Ki Dong; Yoo, Kyung Ho; Kim, Dong Chan; Kim, Dong Jin; Park, Sang Woo Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 13 p. 1421 - 1425

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Citation Number: 17

Abstract

The synthesis and biological activities of a series of new 1β-methylcarbapenems 1a–l having tetrazolothioether moiety at C-5 position of pyrrolidine were described. Among these compounds, 1c showed the most potent antibacterial activity and advanced pharmacokinetics compared with imipenem and meropenem.