Synthesis of 2??amino??4h??thiazolo [5, 4??b] indole and characterization of its colored conversion products with protein tyrosine phosphatase inhibitory activity
Abstract In DMSO-solution 2-amino-4H-thiazolo [5, 4-b] indole is converted into a complex mixture of colored products. The three major conversion end-products, of which two are inhibitors of protein tyrosine phos-phatases (PTPs), were isolated by chromatographic methods and their structures characterized by spectro-scopic analysis, including NMR and MS combined with computer assisted structure elucidation, and, finally, confirmed by ...
