Synthesis of 2??amino??4h??thiazolo [5, 4??b] indole and characterization of its colored conversion products with protein tyrosine phosphatase inhibitory activity

J Breinholt, CB Jeppesen, S Branner…

Index: Breinholt; Jeppesen; Branner; Olsen; Moller; Nielsen; Andersen Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 3 p. 569 - 577

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Citation Number: 5

Abstract

Abstract In DMSO-solution 2-amino-4H-thiazolo [5, 4-b] indole is converted into a complex mixture of colored products. The three major conversion end-products, of which two are inhibitors of protein tyrosine phos-phatases (PTPs), were isolated by chromatographic methods and their structures characterized by spectro-scopic analysis, including NMR and MS combined with computer assisted structure elucidation, and, finally, confirmed by ...