Lipase-mediated kinetic resolution of rigid clofibrate analogues with lipid-modifying activity

…, C Franchini, F Loiodice, MG Perrone, A Scilimati…

文献索引：Ferorelli, Savina; Franchini, Carlo; Loiodice, Fulvio; Perrone, Maria Grazia; Scilimati, Antonio; Sinicropi, Maria Stefania; Tortorella, Paolo Tetrahedron Asymmetry, 2001 , vol. 12, # 6 p. 853 - 862

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被引用次数: 9

摘要

The lipase-catalysed kinetic resolution of methyl esters of (±)-5-chloro-2, 3-dihydro-1- benzofuran-2-carboxylic acid,(±)-6-chloro-2, 3-dihydro-4H-1-benzopyran-2-carboxylic acid, and (±)-6-chloro-2, 3-dihydro-4H-1-benzopyran-3-carboxylic acid, rigid analogues of clofibrate, was effected with fair to moderate enantioselectivities (E= 1.0–4.8), enantiomeric excesses of up to 86% and workable reaction rates. Enantiomerically pure (R)-and (S)-5- ...