The lipase-catalysed kinetic resolution of methyl esters of (±)-5-chloro-2, 3-dihydro-1- benzofuran-2-carboxylic acid,(±)-6-chloro-2, 3-dihydro-4H-1-benzopyran-2-carboxylic acid, and (±)-6-chloro-2, 3-dihydro-4H-1-benzopyran-3-carboxylic acid, rigid analogues of clofibrate, was effected with fair to moderate enantioselectivities (E= 1.0–4.8), enantiomeric excesses of up to 86% and workable reaction rates. Enantiomerically pure (R)-and (S)-5- ...
