Synthesis of new 5??substitutedbenzo [b] thiophene derivatives

S Pérez??Silanes, J Martínez??Esparza…

文献索引：Perez-Silanes; Martinez-Esparza; Oficialdegui; Villanueva; Orus; Monge Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 5 p. 1025 - 1030

全文：HTML全文

被引用次数: 25

摘要

Abstract Previous works of our group have dealt with the synthesis of 1-(aryl)-3-[4-(aryl) piperazin-1-yl] propane derivatives in the search for new and efficient antidepressants with a dual mode of action: serotonin reuptake inhibition and 5-HT 1A receptor afinity [1-4]. From these studies we concluded that the 3-[4-(aryl) piperazin-1-yl]-1-(benzo [b] thiophen-3-yl) propane derivatives led to the best results. The continuation of this research project ...