Design, synthesis, and in vitro antiproliferative activity of novel Dasatinib derivatives

J Cai, S Zhang, M Zheng, X Wu, J Chen, M Ji

文献索引：Cai, Jin; Zhang, Shaoning; Zheng, Ming; Wu, Xiaoqing; Chen, Junqing; Ji, Min Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 806 - 810

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被引用次数: 9

摘要

Two series of novel Dasatinib derivatives have been designed and synthesized, with their in vitro cytostatic effect screened on human chronic myeloid leukemia cell line K562 and human myeloid leukemia cell line U937. Some target compounds demonstrated significant inhibitory activities against both cell lines. Compared to the contrast drug Dasatinib, 1b, 1c, 1d, 1e and 1f were found to demonstrate more potent antitumor activities. The structures of ...