Microwave-assisted hydrolysis of phosphonate diesters: an efficient protocol for the preparation of phosphonic acids

P Jansa, O Baszczyňski, E Procházková…

文献索引：Jansa, Petr; Baszczynski, Ondrej; Prochazkova, Eliska; Dracinsky, Martin; Janeba, Zlatko Green Chemistry, 2012 , vol. 14, # 8 p. 2282 - 2288

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被引用次数: 16

摘要

A new highly efficient method for the hydrolysis of acyclic nucleoside phosphonate diesters (or generally of any organophosphonates) to the corresponding phosphonic acids has been developed. This novel methodology employs inexpensive hydrochloric acid in equimolar amounts to the number of ester groups present in the molecule and thus, avoids using trimethylsilyl halogenides, the standard reagents for these types of transformations. ...