Novel 8-deaza-5, 6, 7, 8-tetrahydroaminopterin derivatives as dihydrofolate inhibitor: Design, synthesis and antifolate activity

Z Zhang, J Wu, F Ran, Y Guo, R Tian, S Zhou…

文献索引：European Journal of Medicinal Chemistry, , vol. 44, # 2 p. 764 - 771

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被引用次数: 12

摘要

... Please enable JavaScript to use all the features on this page. European Journal of Medicinal Chemistry. Volume 44, Issue 2, February 2009, Pages 764–771. ... 1 equiv bromine, DMF, 0 °C to rt, 2 h; (j) allyl bromide (3.5 equiv), NaHCO 3 , THF, rt, 24 h. ...