6-Hydroxy-and 6-methoxy-β-carbolines as acetyl-and butyrylcholinesterase inhibitors

…, M Decker, H Rommelspacher, J Lehmann

文献索引：Schott, Yvonne; Decker, Michael; Rommelspacher, Hans; Lehmann, Jochen Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 22 p. 5840 - 5843

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被引用次数: 51

摘要

In the course of studies directed toward the discovery of novel acetyl-and butyrylcholinesterase (AChE and BChE) inhibitors for the treatment of Alzheimer's disease, we focused on β-carbolines (BCs). 6-Oxygenated β-carboline and β-carbolinium derivatives based on the serotonin template were synthesized and tested in vitro for their ability to inhibit AChE and BChE, respectively. Particularly the carbolinium salts, which can be formed by ...