6-Hydroxy-and 6-methoxy-β-carbolines as acetyl-and butyrylcholinesterase inhibitors

…, M Decker, H Rommelspacher, J Lehmann

Index: Schott, Yvonne; Decker, Michael; Rommelspacher, Hans; Lehmann, Jochen Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 22 p. 5840 - 5843

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Citation Number: 51

Abstract

In the course of studies directed toward the discovery of novel acetyl-and butyrylcholinesterase (AChE and BChE) inhibitors for the treatment of Alzheimer's disease, we focused on β-carbolines (BCs). 6-Oxygenated β-carboline and β-carbolinium derivatives based on the serotonin template were synthesized and tested in vitro for their ability to inhibit AChE and BChE, respectively. Particularly the carbolinium salts, which can be formed by ...