Synthesis and antitubercular activity of novel amino acid derivatives

…, MV De Almeida, M Lourenço…

文献索引：Da Costa, Cristiane F.; Pinheiro, Alessandra C.; De Almeida, Mauro V.; Lourenco, Maria C.S.; De Souza, Marcus V.N. Chemical Biology and Drug Design, 2012 , vol. 79, # 2 p. 216 - 222

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被引用次数: 8

摘要

In this work, 17 new N-acylhydrazone derivatives of amino acids have been evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. The compounds 8b, 8e, 8f, 9a–d, and 10c exhibited an important minimum inhibitory concentration activity between 12.5 and 50 lg⁄ mL, which can be compared with that of the tuberculostatic drug D-cycloserine (20 lg⁄ mL). Key words: amino acids, cell wall, ...