Synthesis of 1, 2, 4-Oxadiazole-, 1, 3, 4-Oxadiazole-, and 1, 2, 4-Triazole-Derived Dipeptidomimetics

S Borg, G Estenne-Bouhtou, K Luthman…

文献索引：Borg, Susanna; Estenne-Bouhtou, Genevieve; Luthman, Kristina; Csoeregh, Ingeborg; Hesselink, Willy; Hacksell, Uli Journal of Organic Chemistry, 1995 , vol. 60, # 10 p. 3112 - 3120

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被引用次数: 158

摘要

Three series of heterocyclic dipeptidomimetics have been synthesized. The compounds were designed as amino acid-glycine mimetics containing 1, 2, 4-oxadiazole, 1, 3, 4- oxadiazole, and 1, 2, 4-triazole ring systems, useful as building blocks in the synthesis of modified peptides. The heterocyclic moieties were chosen according to their geometrical, electrostatical, and hydrogenbonding properties together with the synthetic accessibility. ...