Pharmaceutical research

Hydrotropic solubilization of paclitaxel: analysis of chemical structures for hydrotropic property

J Lee, SC Lee, G Acharya, C Chang, K Park

文献索引：Lee, Jaehwi; Lee, Sang Cheon; Acharya, Ghanashyam; Chang, Ching-Jer; Park, Kinam Pharmaceutical Research, 2003 , vol. 20, # 7 p. 1022 - 1030

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被引用次数: 163

摘要

Abstract Purpose. To identify hydrotropic agents that can increase aqueous paclitaxel (PTX) solubility and to study the chemical structures necessary for hydrotropic properties so that polymeric hydrotropic agents can be synthesized. Methods. More than 60 candidate hydrotropic agents (or hydro-tropes) were tested for their ability to increase the aqueous PTX solubility. A number of nicotinamide analogues were synthesized based on the ...