Indole resin: a versatile new support for the solid-phase synthesis of organic molecules

…, CE Neipp, LM Stephens Stramiello…

文献索引：Estep, Kimberly G.; Neipp, Christopher E.; Stephens Stramiello, Linda M.; Adam, Mavis D.; Allen, Martin P.; Robinson, Shaughnessy; Roskamp, Eric J. Journal of Organic Chemistry, 1998 , vol. 63, # 16 p. 5300 - 5301

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被引用次数: 79

摘要

Combinatorial solid-phase chemistry is gaining momentum throughout the pharmaceutical industry as a powerful tool for preparing libraries of druglike organic molecules. 1 Recent advances have been reviewed. 2 In general terms, solid-phase chemistry can be broken down into three components:(1) the solid support, often a polystyrene resin;(2) the product molecule; and (3) the chemical tether (linker), which connects the two.