Synthesis and antimonoamineoxidase activity of 4-methoxybenzylguanidine and its sulfate

TR Ovsepyan, PR Akopyan, RR Safrazbekyan…

文献索引：Ovsepyan, T. R.; Akopyan, P. R.; Safrazbekyan, R. R.; Sukasyan, R. S.; Arzanunts, E. M.; Sarkisyan, I. S.; Engoyan, A. P.; Karapetyan, A. A.; Struchkov, Yu. T. Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 12 p. 641 - 643 Khimiko-Farmatsevticheskii Zhurnal, 1998 , vol. 32, # 12 p. 18 - 20

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被引用次数: 1

摘要

4-Methoxybenzylguanidine and its sulfate were patented as monoamine oxidase (MAO) inhibitors [1]. However, our attempts to develop efficient synthetic pathways revealed that the physicochemical characteristics available in the literature concerning the structure of these compounds differ from our data and are mutually contradictory. For example, the original work of Saigo [2] reported mp= 210-212~ for 4-methoxybenzylguanidine sulfate, while the ...