2, 4, 6-Trisubstituted pyridines: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship

A Basnet, P Thapa, R Karki, Y Na, Y Jahng…

文献索引：Basnet, Arjun; Thapa, Pritam; Karki, Radha; Na, Younghwa; Jahng, Yurngdong; Jeong, Byeong-Seon; Jeong, Tae Cheon; Lee, Chong-Soon; Lee, Eung-Seok Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 13 p. 4351 - 4359

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被引用次数: 89

摘要

Designed and synthesized were a series of pyridines substituted at 2, 4, and 6 positions with various 5-or 6-memberd heteroaromatics as antitumor agents. They were evaluated their topoisomerase I and II inhibitory activities along with cytotoxicities against several human cancer cell lines. Among the prepared compounds, 10–20 showed significant topoisomerase I or II inhibitory activities, and 21–26 showed considerable cytotoxicities ...