Improved methodologies for the preparation of highly substituted pyridines

Y Fernández Sainz, SA Raw…

文献索引：Sainz, Yolanda Fernandez; Raw, Steven A.; Taylor, Richard J. K. Journal of Organic Chemistry, 2005 , vol. 70, # 24 p. 10086 - 10095

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被引用次数: 62

摘要

Two separate strategies have been developed for the preparation of highly substituted pyridines from 1, 2, 4-triazines via the inverse-electron-demand Diels-Alder reaction: a microwave-promoted, solvent-free procedure and a tethered imine-enamine (TIE) approach. Both routes avoid the need for a discrete aromatization step and offer significant advantages over the classical methods, giving a wide variety of tri-, tetra-, and penta-substituted ...