Bioorganic & medicinal chemistry letters

Substituted 3-(2-benzoxazyl)-benzimidazol-2-(1H)-ones: A new class of GABA A brain receptor ligands

RW DeSimone, CA Blum

文献索引：DeSimone, Robert W.; Blum, Charles A. Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2723 - 2726

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被引用次数: 11

摘要

In the 1980s several benzodiazepine receptor (BZR) ligands with distinct chemical structure were identified that interacted differentially with BZ sites in various brain regions thus supporting the existence of at least two distinct BZR subtypes associated with the GABA A complex. 3 It was also recognized that BZ-receptor ligands within a chemical series (eg, the β-carbolines) are capable of exhibiting a wide range of intrinsic activities from full positive or partial positive ...