Baker's yeast mediated enantiospecific synthesis of anti-(2R, 3R)-p-chloro-3-hydroxytyrosine: an α-amino-β-hydroxy acid of vancomycin

NW Fadnavis, SK Vadivel, M Sharfuddin…

文献索引：Fadnavis; Vadivel, S. Kumara; Sharfuddin; Bhalerao Tetrahedron Asymmetry, 1997 , vol. 8, # 24 p. 4003 - 4006

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被引用次数: 22

摘要

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Baker's yeast mediated reduction of α-azido-β-keto ester lead to reduction of the carbonyl group with high enantiospecificity and diastereoselectivity at low pH (4.0, ee >99%, de 79%). At pH ∼7, although the enantioselectivity is maintained, the diastereoselectivity is lost.