Bioorganic & medicinal chemistry

Control of the intracellular levels of prostaglandin E 2 through inhibition of the 15-hydroxyprostaglandin dehydrogenase for wound healing

D Choi, YL Piao, Y Wu, H Cho

文献索引：Choi, Dubok; Piao, Yu Lan; Wu, Ying; Cho, Hoon Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 15 p. 4477 - 4484

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被引用次数: 5

摘要

Excessive scar formation is an aberrant form of wound healing and is an indication of an exaggerated function of fibroblasts and excess accumulation of extracellular matrix during wound healing. Much experimental data suggests that prostaglandin E2 (PGE2) plays a role in the prevention of excessive scarring. However, it has a very short half-live in blood, its oxidization to 15-ketoprostaglandins is catalyzed by 15-hydroxyprostaglandin ...