Tetrahedron letters

A mild and efficient method for selective cleavage of ketals and acetals using lithium chloride in water-dimethyl sulfoxide

PK Mandal, P Dutta, SC Roy

文献索引：Mandal, Pijus Kumar; Dutta, Pinak; Roy, Subhas Chandra Tetrahedron Letters, 1997 , vol. 38, # 41 p. 7271 - 7274

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被引用次数: 11

摘要

A mild and efficient neutral aqueous method for selective cleavage of acetals and ketals to the corresponding carbonyl compounds has been established by using LiCl in H2O-DMSO at elevated temperature. While aryl and α, β-unsaturated ketals and acetals underwent smooth cleavage, diaryl, non-aryl and isolated ketals and acetals remained unaffected under the reaction conditions.