Tetrahedron letters

Chemoenzymatic synthesis of enantiomerically pure 1, 2-diols employing immobilized lipase in the ionic liquid [bmim] PF 6

A Kamal, G Chouhan

文献索引：Kamal, Ahmed; Chouhan, Gagan Tetrahedron Letters, 2004 , vol. 45, # 48 p. 8801 - 8805

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被引用次数: 54

摘要

1,2-Diols are important precursors and intermediates for a variety of synthetic applications 1 and this functionality is found in a number of pharmaceuticals or their intermediates 2 (Fig. 1). Therefore, the development of methodologies for the preparation of enantiomerically pure 1,2-diols is of considerable interest. Chemical methods for the preparation of optically active 1,2-diols include chiral-pool synthesis, 2a asymmetric hydroxylation, 3 ring opening of ...