Synthesis and evaluation of substituted 4-aryloxy-and 4-arylsulfanyl-phenyl-2-aminothiazoles as inhibitors of human breast cancer cell proliferation

…, SL Mooberry, JH Bushweller, ML Brown

文献索引：Gorczynski, Michael J.; Leal, Rachel M.; Mooberry, Susan L.; Bushweller, John H.; Brown, Milton L. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 5 p. 1029 - 1036

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被引用次数: 62

摘要

Several substituted 4-aryloxy-and 4-arylsulfanyl-phenyl-2-aminothiazoles were synthesized and evaluated for cytotoxic activity against estrogen-positive, estrogen-negative, and adriamycin-resistant human breast cancer cell lines. 4-[4′-(3, 4-Dichlorophenoxy)-phenyl]- thiazol-2-yl ammonium iodide demonstrated potent activity against both estrogen-positive and negative breast cancer cell lines with low micromolar (μM) GI50 values. In addition, ...