Synthesis and antiproliferative effects of novel 5'-fluorinated analogs of 5'-deoxy-5'-(methylthio) adenosine
JR Sufrin, AJ Spiess, DL Kramer…
文献索引：Sufrin, Janice R.; Spiess, Arthur J.; Kramer, Debora L.; Libby, Paul R.; Porter, Carl W. Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 997 - 1001
5'-Deoxy-5'-[(monofluoromethyl) thio] adenosine (9) and 5'-deoxy-5'-fluoro-5'-(methylthio) adenosine (lo), two novel analogues of 5'-deoxy-5'-(methylthio) adenosine (MTA), have been synthesized and evaluated for their substrate and inhibitory activities toward MTA phosphorylase and for their biological effects in L1210 (MTA phosphorylase deficient) and L5178Y (MTA phosphorylase containing) murine leukemia cell lines. Compound 9 was a ...
