Synthesis and antiproliferative effects of novel 5'-fluorinated analogs of 5'-deoxy-5'-(methylthio) adenosine

JR Sufrin, AJ Spiess, DL Kramer…

Index: Sufrin, Janice R.; Spiess, Arthur J.; Kramer, Debora L.; Libby, Paul R.; Porter, Carl W. Journal of Medicinal Chemistry, 1989 ,  vol. 32,  # 5  p. 997 - 1001

Full Text: HTML

Citation Number: 30

Abstract

5'-Deoxy-5'-[(monofluoromethyl) thio] adenosine (9) and 5'-deoxy-5'-fluoro-5'-(methylthio) adenosine (lo), two novel analogues of 5'-deoxy-5'-(methylthio) adenosine (MTA), have been synthesized and evaluated for their substrate and inhibitory activities toward MTA phosphorylase and for their biological effects in L1210 (MTA phosphorylase deficient) and L5178Y (MTA phosphorylase containing) murine leukemia cell lines. Compound 9 was a ...