Streptonigrin and lavendamycin partial structures. Probes for the minimum, potent pharmacophore of streptonigrin, lavendamycin, and synthetic quinoline-5, 8-diones
DL Boger, M Yasuda, LA Mitscher…
文献索引：Boger, Dale L.; Yasuda, Masami; Mitscher, Lester A.; Drake, Steven D.; Kitos, Paul A.; Thompson, Sandra Collins Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1918 - 1928
The preparation and evaluation of 7-amino-5, 8-dioxo-2-(2'-pyridyl) quinoline-6'-carboxylic acid (5a) and 7-amino-2-(2'-aminophe1iyl)-5, 8-dioxoquinoline-5'-c~ boxylic acid (6a) constituting potential minimum, potent pharmacophores of streptonigrin (la) and lavendamycin (2a), two structurally related naturally occurring antitumor antibiotics, are detailed. In contrast to observations associated with streptonigrin and lavendamycin in ...
