Streptonigrin and lavendamycin partial structures. Probes for the minimum, potent pharmacophore of streptonigrin, lavendamycin, and synthetic quinoline-5, 8-diones

DL Boger, M Yasuda, LA Mitscher…

Index: Boger, Dale L.; Yasuda, Masami; Mitscher, Lester A.; Drake, Steven D.; Kitos, Paul A.; Thompson, Sandra Collins Journal of Medicinal Chemistry, 1987 ,  vol. 30,  # 10  p. 1918 - 1928

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Citation Number: 119

Abstract

The preparation and evaluation of 7-amino-5, 8-dioxo-2-(2'-pyridyl) quinoline-6'-carboxylic acid (5a) and 7-amino-2-(2'-aminophe1iyl)-5, 8-dioxoquinoline-5'-c~ boxylic acid (6a) constituting potential minimum, potent pharmacophores of streptonigrin (la) and lavendamycin (2a), two structurally related naturally occurring antitumor antibiotics, are detailed. In contrast to observations associated with streptonigrin and lavendamycin in ...