Iodoacetonitrile and bromoacetonitrile were used to enhance the sensitivity of chromatographically ditficult compounds. Selective derivatization occurs with acidic hydroxyl, amino, and amide functional groups but does not occur for the alcoholic hydroxyl group. Numerous examples of model compounds (eg, phenols, oqganic acids, fatty acids, notisteroidal antiinflammatory drugs, and xanthines) are given. The use of an element- ...
