Tetrahedron letters

Total synthesis of optically active monocrotaline, a carcinogenic pyrrolizidine alkaloid having an 11-membered dilactone

H Niwa, O Okamoto, K Yamada

文献索引：Niwa, Haruki; Okamoto, Osamu; Yamada, Kiyoyuki Tetrahedron Letters, 1988 ,  vol. 29,  # 40  p. 5139 - 5142

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被引用次数: 14

摘要

Abstract Monocrotaline (1), a representative of carcinogenic pyrrolizidine alkaloids with an 11-membered dilactone has been synthesized in optically active form by virtue of regioselective coupling of (+)-retronecine (2) and the protected necic acid 3, the latter being synthesized enantioselectively from the Full-size image (< 1 K)