Chemical Science

… -to-end continuous flow synthesis and purification of diphenhydramine hydrochloride featuring atom economy, in-line separation, and flow of molten ammonium salts

DR Snead, TF Jamison

文献索引：Snead, David R.; Jamison, Timothy F. Chemical Science, 2013 , vol. 4, # 7 p. 2822 - 2827

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被引用次数: 36

摘要

A continuous end-to-end synthesis and purification of diphenhydramine hydrochloride featuring atom economy and waste minimization is described. Combining a 1 [thin space (1/6-em)]:[thin space (1/6-em)] 1 molar ratio of the two starting material streams ( chlorodiphenylmethane and N, N-dimethylaminoethanol) in the absence of additional solvent at high temperature gives the target compound directly as a molten salt (ionic ...