Tetrahedron letters

Direct aldol and tandem Mannich reactions in room temperature ammonia solutions

L Feng, L Xu, K Lam, Z Zhou, CW Yip, ASC Chan

文献索引：Feng, Lichun; Xu, Lijin; Lam, Kimhung; Zhou, Zhongyuan; Yip; Chan, Albert S.C. Tetrahedron Letters, 2005 , vol. 46, # 50 p. 8685 - 8689

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被引用次数: 13

摘要

An economical, simple, and efficient direct aldol reaction via the double activation of both aldehydes and ketones by ammonia has been developed. An unprecedented tandem Mannich reaction was observed when hydroxybenzaldehydes, pyrrole-2-carboxyaldehyde, and indole-3-carboxyaldehyde were employed to afford 2, 2-dimethyl-6-aryl-4-pyrilidinones in moderate to good yields.