2, 3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors

…, JY Ha, JK Choi, KM Lim, CH Lee, S Chung

文献索引：Joo, Yung Hyup; Kim, Jin Kwan; Kang, Seon-Hwa; Noh, Min-Soo; Ha, Jun-Yong; Choi, Jin Kyu; Lim, Kyung Min; Lee, Chang Hoon; Chung, Shin Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 3 p. 413 - 417

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被引用次数: 68

摘要

A new series of cyclooxygenase-2 (COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity. Rational structural modifications were applied to potent COX-2 inhibitors to obtain the desired pharmacokinetic profiles for improved oral anti- inflammatory activity.