Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial β-carbonic anhydrases Rv1284 and Rv3273

O Güzel, A Maresca, A Scozzafava…

文献索引：Katritzky, Alan R.; Manzo, Ruben H. Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1981 , p. 571 - 575

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被引用次数: 59

摘要

... reaction between a pyrylium salt and an amine, leading to pyridinium salts, is in reality a complicated process, as established by detailed spectroscopic and kinetic data from Balaban's and Katritzky's groups.(16 ... inhibitor, R, hCA I c, hCA II c, Rv1284 d, Rv3273 d. ... 3, H, 9.0, 71, 6.5, ...