Reaction of allylzinc bromides with carbonyl compounds in a continuous flow system. Efficient synthesis of homoallyl alcohols including artemisia alcohol
JF Ruppert, JD White
文献索引：Ruppert,J.F.; White,J.D. Journal of Organic Chemistry, 1976 , vol. 41, # 3 p. 550 - 551
Recently we described a procedure in which the Reformatsky reaction is carried out by passing a mixture of an a-bromo ester and an aldehyde or ketone through a heated column of granular zinc.'This continuous-flow adaptation of the conventional synthesis of P-hydroxy esters2 was shown to give substantially improved yields. We have now found that a similar procedure is applicable to the synthesis of alcohols from an allylic bromide and an ...
