A 1, 6-ring closure mechanism for (+)-δ-cadinene synthase?

…, V González, Z Yoosuf-Aly, O Cascón, A Li…

文献索引：Faraldos, Juan A.; Miller, David J.; Gonzalez, Veronica; Yoosuf-Aly, Zulfa; Cascon, Oscar; Li, Amang; Allemann, Rudolf K. Journal of the American Chemical Society, 2012 , vol. 134, # 13 p. 5900 - 5908

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被引用次数: 21

摘要

Recombinant (+)-δ-cadinene synthase (DCS) from Gossypium arboreum catalyzes the metal- dependent cyclization of (E, E)-farnesyl diphosphate (FDP) to the cadinane sesquiterpene δ- cadinene, the parent hydrocarbon of cotton phytoalexins such as gossypol. In contrast to some other sesquiterpene cyclases, DCS carries out this transformation with> 98% fidelity but, as a consequence, leaves no mechanistic traces of its mode of action. The formation ...