Optically Active N??and C??Terminal Building Blocks for the Synthesis of Peptidyl Olefin Peptidomimetics

S Mirilashvili, N Chasid??Rubinstein…

文献索引：Mirilashvili, Sima; Chasid-Rubinstein, Naama; Albeck, Amnon European Journal of Organic Chemistry, 2010 , # 24 p. 4671 - 4686

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被引用次数: 3

摘要

Abstract Peptidyl olefin peptidomimetics serve as biologically active compounds or as intermediates for other peptidyl isosteres. The N-terminal side of the C= C bond could be easily prepared in an optically pure form from α-amino acids. Synthesis of C-terminal building blocks in an optically pure form is more challenging. We developed a chemoenzymatic stereoselective approach to such optically active C-terminal building ...