Design, synthesis and aromatase inhibitory activities of novel indole-imidazole derivatives

R Wang, HF Shi, JF Zhao, YP He, HB Zhang…

文献索引：Wang, Rui; Shi, Hong-Fan; Zhao, Jing-Feng; He, Yan-Ping; Zhang, Hong-Bin; Liu, Jian-Ping Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1760 - 1762

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被引用次数: 13

摘要

A series of novel indole-imidazole derivatives have been prepared and evaluated in vitro on the aromatase inhibitory activities. The results suggested that proton or a small electron- withdrawing group at para-position of the phenyl ring would enhance the inhibitory activities and any bulky group should be avoided in order to keep a relative small volume for this kind of molecules.