Identification and characterization of novel indole based small molecules as anticancer agents through SIRT1 inhibition

…, PV Koushik, M Alvala, P Yogeeswari, D Sriram…

文献索引：Panathur, Naveen; Dalimba, Udayakumar; Koushik, Pulla Venkat; Alvala, Mallika; Yogeeswari, Perumal; Sriram, Dharmarajan; Kumar, Vijith European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 125 - 138

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被引用次数: 10

摘要

Abstract In our pursuit to develop new potential anticancer leads, we designed a combination of structural units of indole and substituted triazole; and a library of 1-{1-methyl- 2-[4-phenyl-5-(propan-2-ylsulfanyl)-4H-1, 2, 4-triazol-3-yl]-1H-indol-3-yl} methanamine derivatives was synthesized and characterized. Cytotoxic evaluations of these molecules over a panel of three human cancer cell lines were carried out. Few molecules exhibited ...