Tetrahedron letters

Synthesis of Cinacalcet congeners

…, R Crockett, J Briones, T Yan, C Orihuela, B Zhi, J Ng

文献索引：Wang, Xin; Chen, Ying; Crockett, Richard; Briones, Jorge; Yan, Tony; Orihuela, Carlos; Zhi, Benxin; Ng, John Tetrahedron Letters, 2004 , vol. 45, # 45 p. 8355 - 8358

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被引用次数: 21

摘要

Two racemic isomeric dihydronaphthalenes 1 and 2 were prepared from commercially available 5-hydroxytetralone in five linear steps. A key palladium-catalyzed double bond migration led to the synthesis of both isomers from the same starting material. Preparative chiral HPLC separation provided the enantiomerically pure materials. An asymmetric synthesis employing CBS reduction to furnish 1 was also developed.