Tetrahedron

Optimization of the reaction conditions using a nadh model grafted on a merrifield type resin

G Dupas, A Decormeille, J Bourguignon, G Quéguiner

文献索引：Dupas, G.; Decormeille, A.; Bourguignon, J.; Queguiner, G. Tetrahedron, 1989 , vol. 45, # 9 p. 2579 - 2590

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被引用次数: 8

摘要

The synthesis of reducing agent 3, 1, 4-dihydronicotinamide grafted on a Merrifield resin, is described. The reaction conditions of reagent 3 are optimized, with respect to the solvent and the catalyst amount. The reagent 3 is more sensitive to traces of water than free NADH models such as N-benzyl 1, 4-dihydronicotinamide. However in hyper-dry conditions reagent 3 is very much more stable and more efficient. It is shown that insertion of a ...