The Journal of Organic Chemistry

A convenient palladium-catalyzed coupling approach to 2, 5-disubstituted pyridines

JW Tilley, S Zawoiski

文献索引：Tilley, Jefferson W.; Zawoiski, Sonja Journal of Organic Chemistry, 1988 , vol. 53, # 2 p. 386 - 390

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被引用次数: 120

摘要

2, 5-Dibromopyridine has been found to undergo a regioselective palladium-catalyzed coupling reaction with terminal acetylenes and arylzinc halides to give the corresponding 2- alkynyl-5-brome and 2-aryl-5-bromopyridines, respectively, in 70%-90% isolated yields. To complement this chemistry, the triflate derived from 2-methyl-5-pyridinol was found to participate in a palladium-catalyzed reaction with terminal acetylenes leading to the ...