Tetrahedron

Zn-promoted regio-and sequence-selective one-pot joining reactions of three components: vinylpyridines, alkyl iodides, and carbonyl compounds (or nitriles)

K Mineyama, H Maekawa, A Kohsaka, Y Yamamoto…

文献索引：Mineyama, Kenji; Maekawa, Hirofumi; Kohsaka, Akihiro; Yamamoto, Yoshimasa; Nishiguchi, Ikuzo Tetrahedron, 2009 , vol. 65, # 36 p. 7706 - 7711

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被引用次数: 2

摘要

Addition of alkyl iodides (3) into the solution containing 2-(or 4-) vinylpyridine (1 or 2) and carbonyl compounds (6) in the presence of Zn-powder (99.9%) in acetonitrile under refluxing brought about regio-and sequence-selective joining reaction of three components to give the corresponding (2-hydroxyethyl) pyridines (7 or 8) in good to moderate yields. On the other hand, 2-(2-or 4-pyridyl) ethyl alkyl ketones (10 or 11) were obtained from the ...