On the antibiotic activity of oxazolomycin

CL Bagwell, MG Moloney, AL Thompson

文献索引：Bagwell, Claire L.; Moloney, Mark G.; Thompson, Amber L. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 14 p. 4081 - 4086

全文：HTML全文

被引用次数: 19

摘要

Structural analysis of oxazolomycin and simpler fragments containing a common 3-hydroxy- 2, 2-dimethylpropanamide moiety has indicated that a U-shaped conformation is preferred, in some cases stabilised by hydrogen bonding between the N–H and O–H residues, as shown by a combination of molecular modelling, NMR spectroscopic and single crystal X- ray analysis. A direct synthesis of this unit has been established via the opening of β- ...