Abstract Structural juxtaposition of the 3, 4, 5-trimethoxyphenyl group in the same molecule with a piperazine or homopiperazine ring has been realized in a series of mescaline analogues (I–IV) as part of an investigation into the pharmacological properties of the seven- membered perhydro-1, 4-diazepines (homopiperazines). The analogous six-membered piperazines were synthesized and tested as reference substances to determine whether ...